Epithelial cytokines and their crimes in severe asthma

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IN THE CRIME OF SEVERE ASTHMA INFLAMMATION:

“Our orders came from the epithelium”

IgE, immunoglobulin E; IL, interleukin; TSLP, thymic stromal lymphopoietin

Focusing on key epithelial cytokines

at the top of the inflammatory cascade (TSLP, IL-33 and IL-25) offers a different way to think about severe asthma.^1-3

FOR SOME PEOPLE WITH SEVERE ASTHMA, THE EPITHELIUM IS THE STARTING POINT FOR AN OVERACTIVE IMMUNE RESPONSE TO VARIOUS INSULTS SUCH AS:^1-3

Release of epithelial cytokines can result in pathologic inflammation, which can cause increased symptoms and asthma exacerbations.^1-3,16

*The mechanisms underlying non-eosinophilic inflammation require further elucidation.

Watch the Mechanism of Disease Video

to learn more about the role of Epithelial Cytokines in severe asthma

Do you have any questions? AstraZeneca's medical experts will be happy to help.

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